Fresh analysis reveals that patients who stop using blockbuster slimming jabs like Mounjaro or Wegovy may regain reduced body mass much more quickly than those who end conventional lifestyle programs.
Published data in a leading medical journal points out that while overweight individuals often shed substantial amounts of their total mass while on the medication, the mass is regained at an estimated rate of 0.8 kg per month once they quit.
"Individuals purchasing such drugs must be aware of the risk of fast rebound weight gain when the medication is stopped," cautioned lead investigator Dr. Susan Jebb.
This pace of recovery suggests a return to original weight in about one and a half years.
Comparing Treatments
The study, which reviewed 37 of trials involving over 9,000 of participants, contrasted the effects of these new drugs with conventional dieting.
Scientists point out that individuals who lose weight through lifestyle changes alone generally see a less rapid creep back—around 0.1 kg a month—once they finish.
Explaining the Quick Rebound
Experts propose the mechanism of the drugs is key to understanding the heightened regain.
The injections copy a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Artificially providing the hormone levels far above than normal may cause the body to produce less of its own natural hormone, and may also diminish sensitivity to its effects," explained Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this hormone supplement leads to hunger is uncontrolled, making excessive eating a significant risk."
A Lifelong Disease?
Health authorities advise the jabs for people with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Many experts contend that, considering the high risk of relapse, the therapy might need to be life-long.
This opinion is echoed by drug manufacturers, who say that the results "underscore the chronic nature of obesity," comparing it to managing diseases like high blood pressure.
Patient Testimonies
People who have discontinued the medication report a intense resurgence of appetite.
"I experienced a trigger flipping and you're instantly extremely hungry," said an individual.
This challenge is exacerbated if patients have not adopted permanent dietary or behavioural modifications during therapy.
Significant Use
Recent estimates suggest that a significant number of people in the UK have tried weight-loss jabs in the past year, with demand continuing to grow.
- Adoption is greater among females compared to men.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion obtain the medications through private prescriptions rather than public health services.
Finally, researchers emphasize that while the jabs are powerful tools for weight loss, they are not a magic solution and maintained weight loss likely depends on ongoing lifestyle support.
